Neurokinin A-induced bronchial hyperresponsiveness to methacholine in Japanese monkeys.
نویسندگان
چکیده
منابع مشابه
Bronchial hyperresponsiveness to methacholine in patients with primary Sjögren's syndrome.
The prevalence of bronchial hyperresponsiveness (BHR) to methacholine inhalation in a consecutive series of 21 patients with primary Sjögren's syndrome was studied prospectively. Slight to severe BHR was seen in 12/20 (60%) of the patients. Ten of 12 patients with BHR (83%) had a non-productive cough, wheezing, or intermittent breathlessness. Bronchial hyperresponsiveness was more common in pat...
متن کاملAllergen-induced Bronchial Hyperresponsiveness
Bradykinin (BK) is a peptide mediator generated at sites of inflammation and its effects are mediated through constitutively expressed B 2 receptor or through induction of B 1 receptors. We examined the role of these receptors in bronchial hyperresponsiveness (BHR). Brown-Norway rats sensitized with ovalbumin (OA) and Al(OH) 3 intraperitoneally, were exposed 3 wk later to either saline or OA ae...
متن کاملChanges in FVC during methacholine-induced bronchoconstriction in elderly patients with asthma: bronchial hyperresponsiveness and aging.
STUDY OBJECTIVE We evaluated whether aging may produce changes in bronchial hyperresponsiveness, risk of enhanced bronchoconstriction, and changes of bronchoconstriction perception. SETTING Each subject underwent a methacholine bronchial challenge. Methacholine challenge was stopped when one of the following conditions occurred: (1) plateau of bronchoconstriction; (2) decrease of FEV(1) > 40%...
متن کاملBronchial hyperresponsiveness to methacholine/AMP and the bronchodilator response in asthmatic children.
Bronchodilator response (BDR) is assessed to estimate the reversibility of airflow obstruction. Bronchial hyperresponsiveness (BHR) is a characteristic feature of asthma and is usually measured by means of bronchial challenges using direct or indirect stimuli. The aim of the present study was to compare BHR to methacholine (direct) and that to adenosine 5'-monophosphate (AMP) (indirect) with re...
متن کاملBronchial hyperresponsiveness to methacholine is associated with increased common carotid intima-media thickness in men.
BACKGROUND Respiratory alterations have been associated with subsequent coronary heart diseases in numerous population-based studies. The underlying mechanisms remain largely unknown. The objective of this study was to examine the association between bronchial hyperresponsiveness (BHR) to methacholine (which reflects local inflammation in the bronchus) and common carotid intima-media thickness ...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1989
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.159.69